SNX1 Contents Function References Further reading External links Navigation menuPDBeRCSB2I4K4FZSSNX1601272192839599716SNX1protein homodimerization activityinsulin receptor bindingleptin receptor bindingepidermal growth factor receptor bindingprotein bindingphosphatidylinositol bindingidentical protein bindingprotein heterodimerization activitytransferrin receptor bindinglipid bindingcadherin bindingcytoplasmcytosolGolgi apparatuscell projectionearly endosome membranemembraneretromer, tubulation complexintracellular membrane-bounded organelleRetromerearly endosomeendosome membranelamellipodiumextrinsic component of membranevesiclelysosomeendosomemacromolecular complexpositive regulation of protein catabolic processvesicle organizationearly endosome to Golgi transportreceptor internalizationendosomal transportretrograde transport, endosome to Golgiprotein transportintracellular protein transportlamellipodium morphogenesisAmigoQuickGO664256440ENSG00000028528ENSMUSG00000032382Q13596Q9WV80NM_001242933NM_003099NM_148955NM_152826NM_019727NP_001229862NP_003090NP_683758NP_062701Chr 15: 64.09 – 64.15 MbChr 9: 66.09 – 66.13 MbGRCh38: Ensembl release 89: ENSG00000028528GRCm38: Ensembl release 89: ENSMUSG00000032382"Human PubMed Reference:""Mouse PubMed Reference:"10.1126/science.272.5264.1008863812110.1016/S1937-6448(08)01204-519081543"Retromer"10.1016/j.ceb.2008.03.009283327418472259"Entrez Gene: sorting nexin 1"10.1074/jbc.M1006062001127910210.1074/jbc.M2069862001219813210.1089/1044549017502324811141016510.1016/j.bbrc.2006.01.1791648794010.1242/jcs.0006531750248610.1111/j.1600-0854.2005.00289.x1588244210.1016/S0014-4827(03)00130-712878157"Determinants of the endosomal localization of sorting nexin 1"10.1091/mbc.E04-06-050410736821567361610.1111/j.1600-0854.2007.00686.x1808832310.1158/1078-0432.CCR-06-03171714581310.1074/jbc.M21100820012657642"Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors"10.1128/MCB.00156-06180068117101778"An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins"10.1091/mbc.E05-09-0899138231216407403"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"10.1101/gr.259650452892815489334"Endosomal localization and function of sorting nexin 1"10.1073/pnas.09214269912447711997453"Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1"10.1091/mbc.E01-11-013111761812058063"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"10.1073/pnas.2426038991392411247793210.1016/j.cub.2004.09.0771549848611309204sorting+nexinseexpanding ite

SNX1SNX2SNX4SNX5SNX6SNX7SNX8SNX9SNX18SNX30SNX32SNX33SNX13SNX14SNX15SNX17SNX19SNX23SNX25SNX26SNX27SNX28SNX31


Genes on human chromosome 15Human chromosome 15 gene stubs


664256440ENSG00000028528ENSMUSG00000032382Q13596Q9WV80proteingenesorting nexinretromerPXphosphoinositidetraffickingendosomalepidermal growth factor receptorprotease-activated receptor-1lysosomes

































SNX1
PDB 2i4k EBI.png


Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases
SNX1, HsT17379, VPS5, sorting nexin 1
External IDsOMIM: 601272 MGI: 1928395 HomoloGene: 99716 GeneCards: SNX1








Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]

Chromosome 15 (human)
Genomic location for SNX1

Genomic location for SNX1

Band15q22.31Start64,094,123 bp[1]
End64,146,090 bp[1]














Orthologs
SpeciesHumanMouse
Entrez

6642

56440

Ensembl

ENSG00000028528

ENSMUSG00000032382

UniProt

Q13596

Q9WV80

RefSeq (mRNA)

NM_001242933
NM_003099
NM_148955
NM_152826

NM_019727

RefSeq (protein)

NP_001229862
NP_003090
NP_683758

NP_062701

Location (UCSC)Chr 15: 64.09 – 64.15 MbChr 9: 66.09 – 66.13 Mb

PubMed search		[3][4]
Wikidata


View/Edit HumanView/Edit Mouse

Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin.[5] SNX1 is a component of the retromer complex.[6][7]




Contents





  • 1 Function


  • 2 References


  • 3 Further reading


  • 4 External links




Function


This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members.[8]



References




  1. ^ abc GRCh38: Ensembl release 89: ENSG00000028528 - Ensembl, May 2017


  2. ^ abc GRCm38: Ensembl release 89: ENSMUSG00000032382 - Ensembl, May 2017


  3. ^ "Human PubMed Reference:"..mw-parser-output cite.citationfont-style:inherit.mw-parser-output .citation qquotes:"""""""'""'".mw-parser-output .citation .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-ws-icon abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center.mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-maintdisplay:none;color:#33aa33;margin-left:0.3em.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em


  4. ^ "Mouse PubMed Reference:".


  5. ^ Kurten RC, Cadena DL, Gill GN (May 1996). "Enhanced degradation of EGF receptors by a sorting nexin, SNX1". Science. 272 (5264): 1008–10. doi:10.1126/science.272.5264.1008. PMID 8638121.


  6. ^ Vergés M (2008). Retromer: multipurpose sorting and specialization in polarized transport. Int Rev Cell Mol Biol. International Review of Cell and Molecular Biology. 271. pp. 153–98. doi:10.1016/S1937-6448(08)01204-5. ISBN 9780123747280. PMID 19081543.


  7. ^ Bonifacino JS, Hurley JH (August 2008). "Retromer". Curr. Opin. Cell Biol. 20 (4): 427–36. doi:10.1016/j.ceb.2008.03.009. PMC 2833274. PMID 18472259.


  8. ^ "Entrez Gene: sorting nexin 1".




Further reading


.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%


  • Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.


  • Cozier GE, Carlton J, McGregor AH, et al. (2002). "The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation". J. Biol. Chem. 277 (50): 48730–6. doi:10.1074/jbc.M206986200. PMID 12198132.


  • Shank BB, Wiley HS, Kurten RC (2001). "Structural and functional characterization of the human gene for sorting nexin 1 (SNX1)". DNA Cell Biol. 20 (5): 287–96. doi:10.1089/104454901750232481. PMID 11410165.


  • Liu H, Liu ZQ, Chen CX, et al. (2006). "Inhibitory regulation of EGF receptor degradation by sorting nexin 5". Biochem. Biophys. Res. Commun. 342 (2): 537–46. doi:10.1016/j.bbrc.2006.01.179. PMID 16487940.


  • Bryant DM, Kerr MC, Hammond LA, et al. (2007). "EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin". J. Cell Sci. 120 (Pt 10): 1818–28. doi:10.1242/jcs.000653. PMID 17502486.


  • Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442.


  • Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.


  • Zhong Q, Watson MJ, Lazar CS, et al. (2005). "Determinants of the endosomal localization of sorting nexin 1". Mol. Biol. Cell. 16 (4): 2049–57. doi:10.1091/mbc.E04-06-0504. PMC 1073682. PMID 15673616.


  • Mari M, Bujny MV, Zeuschner D, et al. (2008). "SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors". Traffic. 9 (3): 380–93. doi:10.1111/j.1600-0854.2007.00686.x. PMID 18088323.


  • Nguyen LN, Holdren MS, Nguyen AP, et al. (2006). "Sorting nexin 1 down-regulation promotes colon tumorigenesis". Clin. Cancer Res. 12 (23): 6952–9. doi:10.1158/1078-0432.CCR-06-0317. PMID 17145813.


  • Pons V, Hullin-Matsuda F, Nauze M, et al. (2003). "Enterophilin-1, a new partner of sorting nexin 1, decreases cell surface epidermal growth factor receptor". J. Biol. Chem. 278 (23): 21155–61. doi:10.1074/jbc.M211008200. PMID 12657642.


  • Rojas R, Kametaka S, Haft CR, Bonifacino JS (2007). "Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors". Mol. Cell. Biol. 27 (3): 1112–24. doi:10.1128/MCB.00156-06. PMC 1800681. PMID 17101778.


  • Gullapalli A, Wolfe BL, Griffin CT, et al. (2006). "An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins". Mol. Biol. Cell. 17 (3): 1228–38. doi:10.1091/mbc.E05-09-0899. PMC 1382312. PMID 16407403.


  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


  • Zhong Q, Lazar CS, Tronchère H, et al. (2002). "Endosomal localization and function of sorting nexin 1". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6767–72. doi:10.1073/pnas.092142699. PMC 124477. PMID 11997453.


  • Wang Y, Zhou Y, Szabo K, et al. (2002). "Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1". Mol. Biol. Cell. 13 (6): 1965–76. doi:10.1091/mbc.E01-11-0131. PMC 117618. PMID 12058063.


  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


  • Carlton J, Bujny M, Peter BJ, et al. (2004). "Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides". Curr. Biol. 14 (20): 1791–800. doi:10.1016/j.cub.2004.09.077. PMID 15498486.


  • Kurten RC, Eddington AD, Chowdhury P, et al. (2001). "Self-assembly and binding of a sorting nexin to sorting endosomes". J. Cell Sci. 114 (Pt 9): 1743–56. PMID 11309204.



External links



  • sorting+nexins at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.








Genes on human chromosome 15, Human chromosome 15 gene stubsUncategorized
-

Popular posts from this blog

Word for a person who has no opinion about whether god existsWord for having a definite opinion while simultaneously withholding judgment?What's the opposite of “newcomer? Is ”veteran" OK?What do you call an “atheist” who might believe in an afterlife?What's a word for someone who wants to voice opinions but not have them challenged?Word for someone who dismisses contrary opinions as irrational?Somone who thinks they are overly special/out of the ordinaryIs there a word, phrase or idiom for “a person who is incapable of thinking about the future”?The belief that a god is human-likeA word for a non-famous person/thing you have heard a lot aboutAdjective for a person who enjoys taking care of their appearance

Image
Reverse string, can I make it faster? How strictly should I take "Candidates must be local"? Are there historical instances of the capital of a colonising country being temporarily or permanently shifted to one of its colonies? Accepted offer letter, position changed Could you please stop shuffling the deck and play already? How to secure an aircraft at a transient parking space? At what distance can a bugbear, holding a reach weapon, with the Polearm Master feat, get their Opportunity Attack? Why was Goose renamed from Chewie for the Captain Marvel film? Is it necessary to separate DC power cables and data cables? Is "history" a male-biased word ("his+story")? Why the color red for the Republican Party What's wrong with this bogus proof? Doesn't allowing a user mode program to access kernel space memory and execute the IN and OUT instructions defeat the purpose of having CPU modes? Can one live in the U.S. and not use a c...
Read more

What was this official D&D 3.5e Lovecraft-flavored rulebook?What was this set of RPG tools called?As a first-time DM should I let my players play complex character classes and roles?Nymph's Kiss and the RelationshipWhat was the name of this Cleric Prestige Class that shapes metal with its bare hands?Are the 3.5e Dragonlance books third party or official works?What's up with the domain Vile Darkness?What was this 80s book about RPGs?What was the name of this Werewolf band?What book had Rituals to “upgrade” animal companions to keep them viable at higher levels?What was this RPG that had rules for player-owned businesses?

Image
Can a Bard use an arcane focus? Indicating multiple different modes of speech (fantasy language or telepathy) The most efficient algorithm to find all possible integer pairs which sum to a given integer A known event to a history junkie How to color a zone in Tikz Simple image editor tool to draw a simple box/rectangle in an existing image Golf game boilerplate Can I use my Chinese passport to enter China after I acquired another citizenship? No idea how to draw this using tikz Is there an Impartial Brexit Deal comparison site? Reply ‘no position’ while the job posting is still there (‘HiWi’ position in Germany) Bob has never been a M before Lifted its hind leg on or lifted its hind leg towards? Can I rely on these GitHub repository files? How do I repair my stair bannister? Pronouncing Homer as in modern Greek What do you call the infoboxes with text and sometimes images on the side of a page we find in textbooks? What will be t...
Read more

2017 IndyCar Series Contents Series news Teams and drivers Schedule Season summary Footnotes References External links Navigation menu"INDYCAR: Initial 2018 bodywork concepts unveiled"the original"IndyCar confirms switch to Performance Friction brakes in 2017""AJ Foyt Racing will switch to Chevy"the original"Carlos Munoz, Conor Daly will drive for AJ Foyt Racing""Zach Veach's Indy 500 Debut Confirmed with Foyt""No mass exodus from Honda after Ganassi switch""Ex-F1 driver Sato joins Andretti Autosport for 2017 IndyCar season""IndyCar's Ryan Hunter-Reay, sponsor DHL paired through 2020""hhgregg and Andretti Autosport announce partnership for key races in 2016""INDYCAR: Rossi re-signs with Andretti"the original"McLaren Formula 1 - Fernando Alonso to race at Indy 500 with McLaren, Honda and Andretti Autosport""Shank will finally take part in Indy 500 with Harvey, Andretti | MotorSportsTalk""Andretti adds Jack Harvey to Indy 500 field""Ganassi switches to Honda power for 2017""INDYCAR: Chilton returns to Ganassi"the original"IndyCar silly season: Who's going where in 2017?""INDYCAR: Kanaan, NTT Data return to Ganassi"the original"Kimball to remain at Ganassi for 2017""Coyne confirms Bourdais for 2017 IndyCar season""Davison to sub for Bourdais in Indy 500"the original"Gutierrez confirmed for Detroit IndyCar debut""Gutierrez returns with Coyne for rest of 2017 season""Vautier to drive for Coyne at Texas"the original"INDYCAR: Coyne confirms Jones for 2017"the original"Pippa Mann returns to Coyne for Indy 500""Karam, Dreyer & Reinbold teaming up again for Indianapolis 500""Pigot to return to Ed Carpenter Racing""Hildebrand confirmed as full-time Ed Carpenter driver""Veach to replace injured Hildebrand at Barber"the originalNew Team Harding Racing Enters Chaves for 101st Indianapolis 500"Juncos Racing Announces Entry in 101st Running of the Indianapolis 500 :: Juncos Racing""Juncos confirms Pigot for Indy 500""Saavedra confirmed in Juncos' second 500 entry"the original"Lazier confirms Indy 500 run after son's USF2000 debut"the original"Claman DeMelo to race for RLLR at Sonoma"the original"Rahal signs Servia and ace engineer for 2017""IndyCar: Aleshin returns with Schmidt"the original"Aleshin replaced by Saavedra for Toronto""Jack Harvey will pilot SPM No. 7 car at Watkins Glen, Sonoma""Jay Howard confirmed in Tony Stewart's supported SPM Indy entry""INDYCAR: Newgarden to wave the flag at Penske"the original"Pagenaud opts for No. 1 in 2017"the original"Penske confirms Newgarden for 2017""Montoya to stay with Team Penske in 2017""Target leaving IndyCar after 27 seasons with Chip Ganassi""Cavin: IndyCar could see complete driver/team shakeup in 2017""End of the road for KV Racing?""KV Racing confirms closure, equipment sold to Juncos""Juncos confirms IndyCar Series entry"the original"Juncos readies IndyCar program, aims for '17 500"the original"Harding Racing to add Texas, Pocono to schedule"the original"Sato signs with Andretti Autosport for 2017""INDYCAR: Aleshin in Doubt at SPM"the original"Long Beach notebook: JR Hildebrand breaks hand""Hildebrand cleared to return at Phoenix"the original"Bourdais to undergo surgery on multiple fractures""Aleshin loses Schmidt Peterson IndyCar ride""Saavedra in at SPM for Pocono, Gateway"the original"Bourdais to make return at Gateway"the original"The IndyCar Grand Prix no longer is sponsored by Angie's List""2017 IndyCar Series rulebook""2017 Verizon IndyCar Series Official Rulebook"Official websiteeeeee

Image
1905190919101911191219131914191519161917191819191920192119221923192419251926192719281929193019311932193319341935193619371938193919401941194619471948194919501951195219531954195519791980198119821983198419851986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200819961996–971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019Kenny BräckBuzz CalkinsScott DixonDario FranchittiSam Hornish Jr.Ryan Hunter-ReayTony KanaanBuddy LazierJosef NewgardenSimon PagenaudWill PowerGreg RayScott SharpTony StewartDan WheldonGatewayIndianapolisIowaPoconoTexasBarberCircuit of the AmericasIndianapolisLaguna SecaMid-OhioPortlandRoad AmericaDetroitLong BeachSt. PetersburgTorontoAtlantaBaltimoreCharlotteChicagolandDoverEdmontonFontanaHomesteadHoustonKansasKentuckyLas VegasLouisianaMichiganMilwaukeeMotegiNashvilleNazarethNew HampshirePhoenixPikes PeakRichmondSão PauloSonomaSurfers ParadiseWalt Disney WorldWatkins GlenBostonBras...
Read more