TCEAL1 References Further reading Navigation menuimprove this articleTCEAL123853173510TCEAL1More reference expression datatranscription factor activity, sequence-specific DNA bindingWW domain bindingcell nucleusnucleoplasmregulation of transcription, DNA-templatednegative regulation of transcription from RNA polymerase II promotertranscription, DNA-templatedAmigoQuickGO9338237052ENSG00000172465ENSMUSG00000049536Q15170Q921P9NM_004780NM_001006639NM_001006640NM_146236NM_001356367NP_001006640NP_001006641NP_004771NP_666348NP_001343296Chr X: 103.63 – 103.63 MbChr X: 136.71 – 136.71 MbGRCh38: Ensembl release 89: ENSG00000172465GRCm38: Ensembl release 89: ENSMUSG00000049536"Human PubMed Reference:""Mouse PubMed Reference:"10.1016/0378-1119(94)90112-08206389"Down-regulation of Rous sarcoma virus long terminal repeat promoter activity by a HeLa cell basic protein"10.1073/pnas.91.23.11002451547971997"Entrez Gene: TCEAL1 transcription elongation factor A (SII)-like 1"10.1074/jbc.270.44.26558759268810.1006/geno.1998.57051005140810.1007/s00109005036510353443"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"10.1073/pnas.24260389913924112477932"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"10.1101/gr.259650452892815489334"The DNA sequence of the human X chromosome"10.1038/nature0344026652861577265110.1111/j.1442-2050.2005.00432.x1577384010.1007/s00335-005-0075-216341674"Large-scale mapping of human protein–protein interactions by mass spectrometry"10.1038/msb4100134184794817353931expanding ite
Genes on human chromosome XHuman chromosome X gene stubs
9338237052ENSG00000172465ENSMUSG00000049536Q15170Q921P9proteingene
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| Aliases | TCEAL1, SIIR, WEX9, p21, pp21, transcription elongation factor A like 1 | ||||||||||||||||||||||||
| External IDs | MGI: 2385317 HomoloGene: 3510 GeneCards: TCEAL1 | ||||||||||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||||||||||
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| Location (UCSC) | Chr X: 103.63 – 103.63 Mb | Chr X: 136.71 – 136.71 Mb | |||||||||||||||||||||||
PubMed search | [3] | [4] | |||||||||||||||||||||||
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Transcription elongation factor A protein-like 1 is a protein that in humans is encoded by the TCEAL1 gene.[5][6][7]
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform.[7]
References
^ abc GRCh38: Ensembl release 89: ENSG00000172465 - Ensembl, May 2017
^ abc GRCm38: Ensembl release 89: ENSMUSG00000049536 - Ensembl, May 2017
^ "Human PubMed Reference:"..mw-parser-output cite.citationfont-style:inherit.mw-parser-output .citation qquotes:"""""""'""'".mw-parser-output .citation .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-ws-icon abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center.mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-maintdisplay:none;color:#33aa33;margin-left:0.3em.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em
^ "Mouse PubMed Reference:".
^ Yeh CH, Shatkin AJ (Jul 1994). "A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII". Gene. 143 (2): 285–7. doi:10.1016/0378-1119(94)90112-0. PMID 8206389.
^ Yeh CH, Shatkin AJ (Dec 1994). "Down-regulation of Rous sarcoma virus long terminal repeat promoter activity by a HeLa cell basic protein". Proc Natl Acad Sci U S A. 91 (23): 11002–6. doi:10.1073/pnas.91.23.11002. PMC 45154. PMID 7971997.
^ ab "Entrez Gene: TCEAL1 transcription elongation factor A (SII)-like 1".
Further reading
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Yeh CH, Zong WX, Shatkin AJ (1995). "The Ser36-Ser37 pair in HeLa nuclear protein p21/SIIR mediates Ser/Thr phosphorylation and is essential for Rous sarcoma virus long terminal repeat repression". J. Biol. Chem. 270 (43): 25313–5. doi:10.1074/jbc.270.44.26558. PMID 7592688.
Pillutla RC, Shimamoto A, Furuichi Y, Shatkin AJ (1999). "Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR". Genomics. 56 (2): 217–20. doi:10.1006/geno.1998.5705. PMID 10051408.
van der Kuip H, Carius B, Haque SJ, et al. (1999). "The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins". J. Mol. Med. 77 (4): 386–92. doi:10.1007/s001090050365. PMID 10353443.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Makino H, Tajiri T, Miyashita M, et al. (2005). "Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis". Dis. Esophagus. 18 (1): 37–40. doi:10.1111/j.1442-2050.2005.00432.x. PMID 15773840.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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Genes on human chromosome X, Human chromosome X gene stubsUncategorized
