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KCNC2 Contents Expression pattern Physiological role Pharmacological properties Transcript variants References External links Navigation menuKCNC29666871199KCNC2potassium channel activityion channel bindingvoltage-gated ion channel activityion channel activityvoltage-gated potassium channel activitydelayed rectifier potassium channel activityvoltage-gated ion channel activity involved in regulation of presynaptic membrane potentialintegral component of membranevesicleperikaryonpostsynaptic membranecell projectionmembranevoltage-gated potassium channel complexplasma membranesynapseintegral component of plasma membraneintracellularneuronal cell body membraneaxoncell junctionterminal boutonneuronal cell bodydendritebasolateral plasma membraneapical plasma membraneaxolemmaneuron projectionpresynaptic membranedendrite membraneresponse to organic cyclic compoundprotein heterooligomerizationregulation of insulin secretionresponse to nerve growth factorregulation of ion transmembrane transportcellular response to toxic substanceresponse to magnesium ionion transportglobus pallidus developmentnitric oxide-cGMP-mediated signaling pathwaypotassium ion transportion transmembrane transporttransmembrane transportresponse to aminepositive regulation of potassium ion transmembrane transportcellular response to nitric oxideresponse to light intensityresponse to ethanolprotein homooligomerizationresponse to toxic substancecellular response to ammonium ionpotassium ion transmembrane transportpositive regulation of voltage-gated potassium channel activityregulation of presynaptic membrane potentialAmigoQuickGO3747268345ENSG00000166006ENSMUSG00000035681Q96PR1Q14B80NM_001260497NM_001260498NM_001260499NM_139136NM_139137NM_153748NM_001025581NM_001359752NM_001359753NP_001247426NP_001247427NP_001247428NP_631874NP_631875NP_715624NP_001020752NP_001346681NP_001346682Chr 12: 75.04 – 75.21 MbChr 10: 112.27 – 112.47 MbGRCh38: Ensembl release 89: ENSG00000166006GRCm38: Ensembl release 89: ENSMUSG00000035681"Human PubMed Reference:""Mouse PubMed Reference:"10.1007/BF00357794811111810.1124/pr.57.4.101638210410.1124/pr.57.4.1016382104"Ionic conductances underlying excitability in tonically firing retinal ganglion cells of adult rat"10.1016/S0166-2236(00)01892-011506885"Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons"10.1523/JNEUROSCI.23-06-02058.20031265766410.1111/j.1749-6632.1999.tb11295.x10414303Kv3.2+Potassium+ChannelKCNC2+protein,+humaneexpanding ite

Inositol trisphosphate receptor123Ryanodine receptor123L-type1.11.21.31.4N-typeP-type2.1Q-typeR-typeT-type3.13.23.312β1β2β3β4γ1γ2γ3γ4Cation channels of sperm1234Two-pore channel12Epithelial sodium channelαβγδAmiloride-sensitive cation channel12341.11.21.31.41.51.61.71.81.97A1234BK channelα1β1β2β3β4SK channelSK1SK2SK3IK11.12.12.22.33.14.14.25.1K_ATP1.12.12.22.32.42.6GIRK3.13.23.33.44.14.25.16.16.27.112345679101213151617181.11.21.31.41.51.61.71.82.12.23.13.23.33.44.14.24.35.16.16.26.36.47.17.27.37.47.58.18.29.19.29.310.110.211.1/hERG11.211.312.112.212.31231234minK/ISKminK/ISK-like123Shaker geneCalcium-activated chloride channelsANO1121234CFTR1234567KAKB123456L11A1BHVCN11234123HCNFC1234TRPA1TRPC12344AP567TRPM12345678TRPML123TRPNTRPP12TRPV123456Aquaporin0123456789Voltage-dependent anion channel123General bacterial porin familyConnexinGJA1GJA3GJA4GJA5GJA8GJA9GJA10GJB1GJB2GJB3GJB4GJB5GJB6GJB7GJC1GJC2GJC3GJD2GJD3GJD4InnexinLigand-gatedLight-gatedVoltage-gatedStretch-activated

Genes on human chromosome 12Ion channelsMembrane protein stubs

3747268345ENSG00000166006ENSMUSG00000035681Q96PR1Q14B80proteingeneproteinvoltage-gated potassium channelneuronsneocortexhippocampuscaudate nucleusretinal ganglion cellstetraethylammonium4-aminopyridinetranscript variantsC-terminal

KCNC2
Identifiers
Aliases	KCNC2, KV3.2, potassium voltage-gated channel subfamily C member 2
External IDs	MGI: 96668 HomoloGene: 71199 GeneCards: KCNC2
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q21.1 Start 75,040,077 bp[1] End 75,209,868 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D2|10 60.3 cM Start 112,271,121 bp[2] End 112,467,024 bp[2]
Gene ontology Molecular function • potassium channel activity • ion channel binding • voltage-gated ion channel activity • ion channel activity • voltage-gated potassium channel activity • delayed rectifier potassium channel activity • voltage-gated ion channel activity involved in regulation of presynaptic membrane potential Cellular component • integral component of membrane • vesicle • perikaryon • postsynaptic membrane • cell projection • membrane • voltage-gated potassium channel complex • plasma membrane • synapse • integral component of plasma membrane • intracellular • neuronal cell body membrane • axon • cell junction • terminal bouton • neuronal cell body • dendrite • basolateral plasma membrane • apical plasma membrane • axolemma • neuron projection • presynaptic membrane • dendrite membrane Biological process • response to organic cyclic compound • protein heterooligomerization • regulation of insulin secretion • response to nerve growth factor • regulation of ion transmembrane transport • cellular response to toxic substance • response to magnesium ion • ion transport • globus pallidus development • nitric oxide-cGMP-mediated signaling pathway • potassium ion transport • ion transmembrane transport • transmembrane transport • response to amine • positive regulation of potassium ion transmembrane transport • cellular response to nitric oxide • response to light intensity • response to ethanol • protein homooligomerization • response to toxic substance • cellular response to ammonium ion • potassium ion transmembrane transport • positive regulation of voltage-gated potassium channel activity • regulation of presynaptic membrane potential Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3747	268345
Ensembl	ENSG00000166006	ENSMUSG00000035681
UniProt	Q96PR1	Q14B80
RefSeq (mRNA)	NM_001260497 NM_001260498 NM_001260499 NM_139136 NM_139137 NM_153748	NM_001025581 NM_001359752 NM_001359753
RefSeq (protein)	NP_001247426 NP_001247427 NP_001247428 NP_631874 NP_631875 NP_715624	NP_001020752 NP_001346681 NP_001346682
Location (UCSC)	Chr 12: 75.04 – 75.21 Mb	Chr 10: 112.27 – 112.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily C member 2 is a protein that in humans is encoded by the KCNC2 gene.^[5][5][6] The protein encoded by this gene is a voltage-gated potassium channel subunit (Kv3.2).^[7]

Contents

• 
  1 Expression pattern
  


• 
  2 Physiological role
  


• 
  3 Pharmacological properties
  


• 
  4 Transcript variants
  


• 
  5 References
  


• 
  6 External links
  

Expression pattern

K_v3.1 and K_v3.2 channels are prominently expressed in neurons that fire at high frequency. K_v3.2 channels are prominently expressed in brain (fast-spiking GABAergic interneurons of the neocortex, hippocampus, and caudate nucleus; terminal fields of thalamocortical projections), and in retinal ganglion cells.^[8][9][7]

Physiological role

K_v3.1/K_v3.2 conductance is necessary and kinetically optimized for high-frequency action potential generation.^[9][10] Sometimes in heteromeric complexes with K_v3.1; important for the high-frequency firing of fast spiking GABAergic interneurons and retinal ganglion cells; and GABA release via regulation of action potential duration in presynaptic terminals.^[7][8]

Pharmacological properties

K_v3.2 currents in heterologous systems are highly sensitive to external tetraethylammonium (TEA) or 4-aminopyridine (4-AP) (IC₅₀ values are 0.1 mM for both of the drugs).^[7][9] This can be useful in identifying native channels.^[9]

Transcript variants

There are four transcript variants of K_v3.2 gene: K_v3.2a, K_v3.2b, K_v3.2c, K_v3.2d. K_v3.2 isoforms differ only in their C-terminal sequence.^[11]

References

1. 
   ^ ^abc GRCh38: Ensembl release 89: ENSG00000166006 - Ensembl, May 2017
   


2. 
   ^ ^abc GRCm38: Ensembl release 89: ENSMUSG00000035681 - Ensembl, May 2017
   


3. 
   ^ "Human PubMed Reference:"..mw-parser-output cite.citationfont-style:inherit.mw-parser-output .citation qquotes:"""""""'""'".mw-parser-output .citation .cs1-lock-free abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .citation .cs1-lock-subscription abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registrationcolor:#555.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration spanborder-bottom:1px dotted;cursor:help.mw-parser-output .cs1-ws-icon abackground:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center.mw-parser-output code.cs1-codecolor:inherit;background:inherit;border:inherit;padding:inherit.mw-parser-output .cs1-hidden-errordisplay:none;font-size:100%.mw-parser-output .cs1-visible-errorfont-size:100%.mw-parser-output .cs1-maintdisplay:none;color:#33aa33;margin-left:0.3em.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-formatfont-size:95%.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-leftpadding-left:0.2em.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-rightpadding-right:0.2em
   


4. 
   ^ "Mouse PubMed Reference:".
   


5. 
   ^ ^ab Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B (Mar 1994). "Localization of Shaw-related K+ channel genes on mouse and human chromosomes". Mamm Genome. 4 (12): 711–5. doi:10.1007/BF00357794. PMID 8111118.
   


6. 
   ^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
   


7. 
   ^ ^abcd Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
   


8. 
   ^ ^ab Kolodin YO (2008-04-27). "Ionic conductances underlying excitability in tonically firing retinal ganglion cells of adult rat". Retrieved 2008-10-20.
   


9. 
   ^ ^abcd Rudy B, McBain CJ (September 2001). "K_v3 channels: voltage-gated K⁺ channels designed for high-frequency repetitive firing". Trends in Neurosciences. 24 (9): 517–26. doi:10.1016/S0166-2236(00)01892-0. PMID 11506885.
   


10. 
    ^ Lien CC, Jonas P (March 2003). "K_v3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons". Journal of Neuroscience. 23 (6): 2058–68. doi:10.1523/JNEUROSCI.23-06-02058.2003. PMID 12657664.
    


11. 
    ^ Rudy B, Chow A, Lau D, Amarillo Y, Ozaita A, Saganich M, Moreno H, Nadal MS, Hernandez-Pineda R, Hernandez-Cruz A, Erisir A, Leonard C, Vega-Saenz de Miera E (April 1999). "Contributions of K_v3 channels to neuronal excitability". Annals of the New York Academy of Sciences. 868 (1 MOLECULAR AND): 304–43. doi:10.1111/j.1749-6632.1999.tb11295.x. PMID 10414303.
    

External links

• 
  Kv3.2+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)


• 
  KCNC2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

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Genes on human chromosome 12, Ion channels, Membrane protein stubsUncategorized