• response to organic cyclic compound • protein heterooligomerization • regulation of insulin secretion • response to nerve growth factor • regulation of ion transmembrane transport • cellular response to toxic substance • response to magnesium ion • ion transport • globus pallidus development • nitric oxide-cGMP-mediated signaling pathway • potassium ion transport • ion transmembrane transport • transmembrane transport • response to amine • positive regulation of potassium ion transmembrane transport • cellular response to nitric oxide • response to light intensity • response to ethanol • protein homooligomerization • response to toxic substance • cellular response to ammonium ion • potassium ion transmembrane transport • positive regulation of voltage-gated potassium channel activity • regulation of presynaptic membrane potential
Potassium voltage-gated channel subfamily C member 2 is a protein that in humans is encoded by the KCNC2 gene.[5][5][6] The protein encoded by this gene is a voltage-gated potassium channel subunit (Kv3.2).[7]
Contents
1Expression pattern
2Physiological role
3Pharmacological properties
4Transcript variants
5References
6External links
Expression pattern
Kv3.1 and Kv3.2 channels are prominently expressed in neurons that fire at high frequency. Kv3.2 channels are prominently expressed in brain (fast-spiking GABAergic interneurons of the neocortex, hippocampus, and caudate nucleus; terminal fields of thalamocortical projections), and in retinal ganglion cells.[8][9][7]
Physiological role
Kv3.1/Kv3.2 conductance is necessary and kinetically optimized for high-frequency action potential generation.[9][10] Sometimes in heteromeric complexes with Kv3.1; important for the high-frequency firing of fast spiking GABAergic interneurons and retinal ganglion cells; and GABA release via regulation of action potential duration in presynaptic terminals.[7][8]
Pharmacological properties
Kv3.2 currents in heterologous systems are highly sensitive to external tetraethylammonium (TEA) or 4-aminopyridine (4-AP) (IC50 values are 0.1 mM for both of the drugs).[7][9] This can be useful in identifying native channels.[9]
Transcript variants
There are four transcript variants of Kv3.2 gene: Kv3.2a, Kv3.2b, Kv3.2c, Kv3.2d. Kv3.2 isoforms differ only in their C-terminal sequence.[11]
References
^ abcGRCh38: Ensembl release 89: ENSG00000166006 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000035681 - Ensembl, May 2017
^ abHaas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B (Mar 1994). "Localization of Shaw-related K+ channel genes on mouse and human chromosomes". Mamm Genome. 4 (12): 711–5. doi:10.1007/BF00357794. PMID 8111118.
^Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
^ abcdGutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
^ abKolodin YO (2008-04-27). "Ionic conductances underlying excitability in tonically firing retinal ganglion cells of adult rat". Retrieved 2008-10-20.
^ abcdRudy B, McBain CJ (September 2001). "Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing". Trends in Neurosciences. 24 (9): 517–26. doi:10.1016/S0166-2236(00)01892-0. PMID 11506885.
^Lien CC, Jonas P (March 2003). "Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons". Journal of Neuroscience. 23 (6): 2058–68. doi:10.1523/JNEUROSCI.23-06-02058.2003. PMID 12657664.
^Rudy B, Chow A, Lau D, Amarillo Y, Ozaita A, Saganich M, Moreno H, Nadal MS, Hernandez-Pineda R, Hernandez-Cruz A, Erisir A, Leonard C, Vega-Saenz de Miera E (April 1999). "Contributions of Kv3 channels to neuronal excitability". Annals of the New York Academy of Sciences. 868 (1 MOLECULAR AND): 304–43. doi:10.1111/j.1749-6632.1999.tb11295.x. PMID 10414303.
External links
Kv3.2+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
KCNC2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
v
t
e
Membrane transport protein: ion channels (TC 1A)
Ca2+: Calcium channel
Ligand-gated
Inositol trisphosphate receptor
1
2
3
Ryanodine receptor
1
2
3
Voltage-gated
L-type/Cavα
1.1
1.2
1.3
1.4
N-type/Cavα2.2
P-type/Cavα
2.1
Q-type/Cavα2.1
R-type/Cavα2.3
T-type/Cavα
3.1
3.2
3.3
α2δ-subunits
1
2
β-subunits
β1
β2
β3
β4
γ-subunits
γ1
γ2
γ3
γ4
Cation channels of sperm
1
2
3
4
Two-pore channel
1
2
Na+: Sodium channel
Constitutively active
Epithelial sodium channel
α
β
γ
δ
Proton-gated
Amiloride-sensitive cation channel
1
2
3
4
Voltage-gated
Navα
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
7A
Navβ
1
2
3
4
K+: Potassium channel
Calcium-activated
BK channel
α1
β1
β2
β3
β4
SK channel
SK1
SK2
SK3
IK channel
IK1
KCa
1.1
2.1
2.2
2.3
3.1
4.1
4.2
5.1
Inward-rectifier
KATP
Kir
1.1
2.1
2.2
2.3
2.4
2.6
GIRK/Kir
3.1
3.2
3.3
3.4
Kir
4.1
4.2
5.1
6.1
6.2
7.1
Tandem pore domain
K2P
1
2
3
4
5
6
7
9
10
12
13
15
16
17
18
Voltage-gated
Kvα1-6
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
2.1
2.2
3.1
3.2
3.3
3.4
4.1
4.2
4.3
5.1
6.1
6.2
6.3
6.4
Kvα7-12
7.1
7.2
7.3
7.4
7.5
8.1
8.2
9.1
9.2
9.3
10.1
10.2
11.1/hERG
11.2
11.3
12.1
12.2
12.3
Kvβ
1
2
3
KCNIP
1
2
3
4
minK/ISK
minK/ISK-like
MiRP
1
2
3
Shaker gene
Miscellaneous
Cl−: Chloride channel
Calcium-activated chloride channels
Anoctamin
ANO1
Bestrophin
1
2
Chloride Channel Accessory
1
2
3
4
CFTR
CLCN
1
2
3
4
5
6
7
KA
KB
CLIC
1
2
3
4
5
6
L1
CLNS
1A
1B
H+: Proton channel
HVCN1
M+: CNG cation channel
α
1
2
3
4
β
1
2
3
HCN
FC
1
2
3
4
M+: TRP cation channel
TRPA (1)
TRPC
1
2
3
4
4AP
5
6
7
TRPM
1
2
3
4
5
6
7
8
TRPML
1
2
3
TRPN
TRPP
1
2
TRPV
1
2
3
4
5
6
H2O (+ solutes): Porin
Aquaporin
0
1
2
3
4
5
6
7
8
9
Voltage-dependent anion channel
1
2
3
General bacterial porin family
Cytoplasm: Gap junction
Connexin
A
GJA1
GJA3
GJA4
GJA5
GJA8
GJA9
GJA10
B
GJB1
GJB2
GJB3
GJB4
GJB5
GJB6
GJB7
C
GJC1
GJC2
GJC3
D
GJD2
GJD3
GJD4
Innexin
By gating mechanism
Ion channel class
Ligand-gated
Light-gated
Voltage-gated
Stretch-activated
see also disorders
This membrane protein–related article is a stub. You can help Wikipedia by expanding it.
SurnamesCzech-language surnames ‹ The template Infobox surname is being considered for merging. › Frič Origin Language(s) Czechized German (eastern Middle German dialects and Alemannic German) - Thuringian, Upper Saxon, Low Lusatian, Silesian Meaning derived from German: Friedrich Other names Variant(s) Fritsch, Fritzsch, Frycz, Fricz, Fryczyński, Frietsch, Fritsche, Fritzsche; Fritschi (Alemannic), Fritz, Fritze, Fritzel, Fritzl, Fritzke, Fritzen Frič is a Czechized German surname. Notable people with the surname include: Alberto Vojtěch Frič, Czech botanist Antonín Jan Frič (Fritsch) , Czech paleontologist Jaroslav Erik Frič, Czech poet Martin Frič, Czech film director, screenwriter and actor See also Fričovce (Hungarian: Frics ) .mw-parser-output table.dmboxclear:both;margin:0.9em 1em;border-top:1px solid #ccc;border-bottom:1px solid #ccc;background-color:transparent Surname list This page lists people with...
Apollo command module space walk? prime numbers and expressing non-prime numbers Can a non-EU citizen traveling with me come with me through the EU passport line? Extract all GPU name, model and GPU ram How to deal with a team lead who never gives me credit? Why was the term "discrete" used in discrete logarithm? Why do we bend a book to keep it straight? When do you get frequent flier miles - when you buy, or when you fly? How come Sam didn't become Lord of Horn Hill? At the end of Thor: Ragnarok why don't the Asgardians turn and head for the Bifrost as per their original plan? Is it true that "carbohydrates are of no use for the basal metabolic need"? Using et al. for a last / senior author rather than for a first author How to tell that you are a giant? How to react to hostile behavior from a senior developer? String `!23` is replaced with `docker` in command line How to find out what spells would be useless to a blind NPC sp...
How to type this arrow in math mode? Multiply Two Integer Polynomials What do hard-Brexiteers want with respect to the Irish border? Why isn't the circumferential light around the M87 black hole's event horizon symmetric? For what reasons would an animal species NOT cross a *horizontal* land bridge? Can one be advised by a professor who is very far away? Identify boardgame from Big movie slides for 30min~1hr skype tenure track application interview Why do we hear so much about the Trump administration deciding to impose and then remove tariffs? If I score a critical hit on an 18 or higher, what are my chances of getting a critical hit if I roll 3d20? Can we generate random numbers using irrational numbers like π and e? Worn-tile Scrabble Output the Arecibo Message What is the meaning of Triage in Cybersec world? How are circuits which use complex ICs normally simulated? Shouldn't "much" here be used instead of "more"? Dele...
